Cannabis and Depression

How can plant-based cannabinoids offer benefits for Depression? Read Bonni Goldstein MD's summary of the research on cannabis and Depression.

Cannabinoids, including CBD, CBG, and CBDA, interact with the endocannabinoid system, which helps regulate mood, stress response, and emotional balance. Preclinical studies in animals suggest that cannabinoids may reduce symptoms of depression, improve stress resilience and support balanced brain function and communication between brain cells. Clinical studies in humans indicate that cannabinoids may help reduce depressive symptoms. Working with a knowledgeable clinician can ensure safe and effective benefits for depression and other mood disorders. 

Sources

Martin, Erin L., et al. "Antidepressant and anxiolytic effects of medicinal cannabis use in an observational trial." Frontiers in psychiatry 12 (2021: 729800.; Reuveni, Noa, et al. "The antidepressant and anxiolytic effects of cannabinoids in chronic unpredictable stress: a preclinical systematic review and meta-analysis." Translational Psychiatry 12.12022: 217.; Hasbi, Ahmed, Bertha K. Madras, and Susan R. George. "Endocannabinoid system and exogenous cannabinoids in depression and anxiety: a review." Brain sciences 13.22023: 325.)

 

With over two decades of clinical experience, Dr. Goldstein is the CEO and co-founder of Goldstein Wellness and serves as the Medical Director/Owner of Canna-Centers Wellness & Education. Her patient roster, numbering over 20,000 individuals, includes more than two thousand children who have benefited from medical cannabis under her care.
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